Erasca, Inc.

We are a clinical-stage precision oncology company, founded in 2018. We focus on discovering, developing, and commercializing therapies for RAS- and MAPK pathway-driven cancers, which affect about 5.5 million people worldwide each year.

Our approach uses a variety of treatments —small molecules, large molecules, and protein degraders —either alone or in combination. We have three main strategies to disrupt RAS/MAPK signaling: targeting nodes upstream and downstream of MAPK (MAPKlampTM), directly targeting RAS, and targeting escape routes through other proteins or pathways.

We also have environmental, social, and governance (ESG) initiatives. For example, the Erasca Foundation, started in May 2021, funds cancer research, patient advocacy, and support for underserved populations. Our offices are LEED certified (San Diego Gold, San Francisco Platinum) and include features like electric vehicle charging stations, indoor bike racks, and employee recycling programs.

If our products become commercially available, we plan to ensure inclusive clinical trial participation and provide drug access through patient assistance and compassionate use programs. We have offices in San Diego, California, and South San Francisco.

Our mission is simple: “To erase cancer.” Our vision is to one day erase cancer in at least 100,000 patients annually. This means patients who are alive and free of cancer or progression two years after treatment.

Our corporate values, which spell out CURE, are:

• Committed to erasing cancer in patients.
• United by trust, respect, and integrity.
• Relentlessly focused on team-based execution with agility, creativity, and fun.
• Exceptional innovation with world-class collaborators.

We have between 51 and 200 employees and partner with world-class collaborators. Our work environment is collaborative, respectful, and transparent, encouraging everyone to participate.

Our culture values the urgency of our mission, while also believing that serious science can be “serious fun.” We call ourselves “Erascals,” and we look for people who are mission-driven, strategic, team players, and adaptable, bringing creativity and a focus on results.

We offer a comprehensive benefits package, including compensation and incentive programs, annual bonus potential, and equity grants (like stock options or an Employee Stock Purchase Program) when you’re hired and annually.

Our health and wellness benefits cover:

• Medical, Dental, and Vision Plans
• Short- and Long-Term Disability
• Basic and Voluntary Life/AD&D Coverage
• Flexible Spending Accounts (FSA, HSA, and Commute)
• Critical Illness and Accident Coverage
• Pet Insurance
• Employee Assistance Program

Additional perks include Paid Time Off, Holiday, and Sick Leave, plus a 401(k) Plan with our contribution. Some roles may also offer hybrid or fully remote work options within the United States.