Madrigal Pharmaceuticals

Founded in 2016, we are a biopharmaceutical company developing novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH). MASH is a serious fatty liver disease that can cause progressive liver scarring (fibrosis), cirrhosis, liver failure, liver cancer, transplant needs, and early death. We aim to halt or reverse liver scarring and resolve MASH before patients experience these severe complications.

Our research program identified a thyroid hormone receptor-β (THR-β) agonist as our lead therapeutic candidate. In 2024, we received the first U.S. Food and Drug Administration (FDA) approval for a MASH treatment and subsequently launched it in the U.S.

What started as a small team in Conshohocken, Pennsylvania, has grown into a fully integrated biopharmaceutical company operating in the United States and Europe. Our corporate headquarters are in West Conshohocken, PA, with additional offices in Waltham, MA, and Zug, Switzerland.

Our purpose is to lead the fight against MASH. We aim to protect patients and the health system by halting and reversing MASH before severe complications like cirrhosis, liver cancer, liver transplant, or early death occur.

Our culture is built on our Core Values:

• Patient Focus: We prioritize patients to guide our work, developing new treatments for MASH and addressing unmet needs.
• Owner Mindset: We take individual accountability and ownership to achieve results and deliver on our promises.
• Relentless Pursuit of Innovation: We think creatively, solve problems, and embrace new ideas to drive innovation.
• Commitment to Collaboration: We foster an inclusive and collaborative culture, recognizing that every success comes from teamwork and a shared passion to improve lives.

We are a fully integrated biopharmaceutical company with 501-1000 employees across the United States and Europe. Every team member shares the purpose of leading the fight against MASH.

We foster a collaborative, respectful, and entrepreneurial culture. We bring together individuals with diverse backgrounds and expertise, all dedicated to making a meaningful difference in the lives of people living with MASH. We are an Equal Opportunity Employer, basing employment decisions on qualifications, merit, and business need.